The HMGA2 Polyclonal Antibody (CAB2972) is a valuable tool for researchers studying the HMGA2 protein, a transcriptional regulator that plays a key role in cell growth and differentiation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting.HMGA2 is known for its involvement in various cellular processes, including chromatin remodeling and gene regulation, making it a crucial target for research in fields such as cancer biology and developmental biology.
By detecting and analyzing HMGA2 protein expression, researchers can gain insights into its functions and potential roles in diseases such as cancer.The HMGA2 Polyclonal Antibody offers researchers a reliable tool for investigating the cellular functions of HMGA2 and its implications in various physiological and pathological conditions. Its high specificity and sensitivity make it an essential resource for studies aimed at understanding the molecular mechanisms governed by HMGA2.
Product Name:
HMGA2 Rabbit Polyclonal Antibody
SKU:
CAB2972
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 55-109 of human HMGA2 (NP_003474.1).
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
8091
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HMGA2 Rabbit pAb (CAB2972) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
