null

HM13 Antibody (PACO39734)

SKU:
PACO39734
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • HM13 Antibody PACO39734
  • HM13 Antibody PACO39734
$407

Description

system_update_altDatasheetsystem_update_altMSDS

HM13 Antibody (PACO39734)

The HM13 Polyclonal Antibody is a valuable tool for researchers studying the CD300A protein, a key player in immune regulation. This antibody, produced in rabbits, is highly reactive with human samples and is specifically designed for use in Western blot applications. By binding to CD300A, this antibody allows for the detection and analysis of this important cell surface molecule in various cell types.CD300A, also known as an immune inhibitory receptor, is essential for maintaining immune homeostasis by regulating inflammation and inhibiting allergic reactions.

Its role in immune response modulation makes it a promising target for research in areas such as immunology and cancer research. By understanding the activity of CD300A, researchers can potentially develop therapies for diseases like cancer, autoimmune disorders, and chronic inflammatory conditions that involve immune dysregulation.Overall, the HM13 Polyclonal Antibody is a crucial tool for researchers looking to delve deeper into the functions of CD300A and its implications for immune system regulation and disease pathogenesis.

Antibody Name:HM13 Antibody (PACO39734)
Antibody SKU:PACO39734
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200
Species Reactivity:Human, Mouse
Immunogen:Recombinant Human Minor histocompatibility antigen H13 protein (336-377AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot. All lanes: HM13 antibody at 6µg/ml + Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 42, 47, 44, 37 kDa. Observed band size: 42 kDa.
Product ImageImmunofluorescent analysis of 293 cells using PACO39734 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner. May play a role in graft rejection (By similarity).
Synonyms:Minor histocompatibility antigen H13 (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase), HM13, H13 IMP1 PSL3 SPP
UniProt Protein Function:HM13: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Belongs to the peptidase A22B family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; EC 3.4.23.-; Membrane protein, multi-pass; Endoplasmic reticulum; ProteaseChromosomal Location of Human Ortholog: 20q11.21Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum membrane; lysosomal membrane; membrane; rough endoplasmic reticulumMolecular Function: aspartic endopeptidase activity, intramembrane cleaving; peptidase activity; protein binding; protein homodimerization activity; ubiquitin protein ligase bindingBiological Process: membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; membrane protein proteolysis; protein homotetramerization; signal peptide processing
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q8TCT9
NCBI GenInfo Identifier:25008563
NCBI Gene ID:81502
NCBI Accession:Q8TCT9.1
UniProt Secondary Accession:Q8TCT9,Q15K36, Q540H8, Q5JWP2, Q5JWP3, Q5JWP4, Q5JWP5 Q7Z4F2, Q86Y35, Q95H87
UniProt Related Accession:Q8TCT9
Molecular Weight:36,814 Da
NCBI Full Name:Minor histocompatibility antigen H13
NCBI Synonym Full Names:histocompatibility minor 13
NCBI Official Symbol:HM13  
NCBI Official Synonym Symbols:H13; SPP; IMP1; PSL3; IMPAS; SPPL1; PSENL3; IMPAS-1; MSTP086  
NCBI Protein Information:minor histocompatibility antigen H13
UniProt Protein Name:Minor histocompatibility antigen H13
UniProt Synonym Protein Names:Intramembrane protease 1; IMP-1; IMPAS-1; hIMP1; Presenilin-like protein 3; Signal peptide peptidase
Protein Family:Minor histocompatibility antigen
UniProt Gene Name:HM13  
UniProt Entry Name:HM13_HUMAN
Antibodies
HM13 Antibody (PACO09739)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

Related Products