HLA-DRB3 Rabbit Polyclonal Antibody (CAB12444)
- SKU:
- CAB12444
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | HLA-DRB3 Rabbit Polyclonal Antibody |
SKU: | CAB12444 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-227 of human HLA-DRB3 (NP_072049.2). |
Sequence: | GDTR PRFL ELRK SECH FFNG TERV RYLD RYFH NQEE FLRF DSDV GEYR AVTE LGRP VAES WNSQ KDLL EQKR GRVD NYCR HNYG VGES FTVQ RRVH PQVT VYPA KTQP LQHH NLLV CSVS GFYP GSIE VRWF RNGQ EEKA GVVS TGLI QNGD WTFQ TLVM LETV PRSG EVYT CQVE HPSV TSAL TVEW RARS ESAQ SK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | DRB3; HLA-DPB1; HLA-DR1B; HLA-DR3B; HLA-DRB3; HLA-DRB3 |
Positive Sample: | Raji,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Endoplasmic reticulum membrane, Endosome membrane, Golgi apparatus, Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein, trans-Golgi network membrane. |
Calculated MW: | 30kDa |
Observed MW: | 30kDa |
HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene.
Purification Method: | Affinity purification |
Gene ID: | 3125 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |