HLA-DRB1 Rabbit Polyclonal Antibody (CAB7685)
- SKU:
- CAB7685
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | HLA-DRB1 Rabbit Polyclonal Antibody |
SKU: | CAB7685 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-230 of human HLA-DRB1 (NP_002115.2). |
Sequence: | GDTR PRFL WQPK RECH FFNG TERV RFLD RYFY NQEE SVRF DSDV GEFR AVTE LGRP DAEY WNSQ KDIL EQAR AAVD TYCR HNYG VVES FTVQ RRVQ PKVT VYPS KTQP LQHH NLLV CSVS GFYP GSIE VRWF LNGQ EEKA GMVS TGLI QNGD WTFQ TLVM LETV PRSG EVYT CQVE HPSV TSPL TVEW RARS ESAQ SKML S |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SS1; DRB1; HLA-DRB; HLA-DR1B; HLA-DRB1 |
Positive Sample: | MCF7,Mouse thymus,Mouse spleen,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Endoplasmic reticulum membrane, Endosome membrane, Golgi apparatus, Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein, trans-Golgi network membrane. |
Calculated MW: | 30kDa |
Observed MW: | 30kDa |
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene.
Purification Method: | Affinity purification |
Gene ID: | 3123 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |