HLA-DRA Rabbit Polyclonal Antibody (CAB11787)
- SKU:
- CAB11787
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | HLA-DRA Rabbit Polyclonal Antibody |
SKU: | CAB11787 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-216 of human HLA-DRA (NP_061984.2). |
Sequence: | IKEE HVII QAEF YLNP DQSG EFMF DFDG DEIF HVDM AKKE TVWR LEEF GRFA SFEA QGAL ANIA VDKA NLEI MTKR SNYT PITN VPPE VTVL TNSP VELR EPNV LICF IDKF TPPV VNVT WLRN GKPV TTGV SETV FLPR EDHL FRKF HYLP FLPS TEDV YDCR VEHW GLDE PLLK HWEF DAPS PLPE TTE |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | HLA-DRA1; HLA-DRA |
Positive Sample: | Raji,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Endoplasmic reticulum membrane, Endosome membrane, Golgi apparatus, Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein, trans-Golgi network membrane. |
Calculated MW: | 29kDa |
Observed MW: | 36kDa |
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Purification Method: | Affinity purification |
Gene ID: | 3122 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |