HLA-DQA1 Rabbit Polyclonal Antibody (CAB2168)
- SKU:
- CAB2168
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Product Name: | HLA-DQA1 Rabbit Polyclonal Antibody |
SKU: | CAB2168 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-216 of human HLA-DQA1 (NP_002113.2). |
Sequence: | EDIV ADHV ASCG VNLY QFYG PSGQ YTHE FDGD EQFY VDLE RKET AWRW PEFS KFGG FDPQ GALR NMAV AKHN LNIM IKRY NSTA ATNE VPEV TVFS KSPV TLGQ PNTL ICLV DNIF PPVV NITW LSNG QSVT EGVS ETSF LSKS DHSF FKIS YLTF LPSA DEIY DCKV EHWG LDQP LLKH WEPE IPAP MSEL T |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | DQA1; DQ-A1; CELIAC1; HLA-DQA; HLA-DQB1; HLA-DQA1*; HLA-DQA1 |
Positive Sample: | SW620,HT-29,Lovo,Mouse brain,Mouse stomach |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Endoplasmic reticulum membrane, Endosome membrane, Golgi apparatus, Lysosome membrane, Single-pass type I membrane protein, trans-Golgi network membrane. |
Calculated MW: | 28kDa |
Observed MW: | 28kDaa-37kDa |
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
Purification Method: | Affinity purification |
Gene ID: | 3117 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |