HLA-DPB1 Rabbit Polyclonal Antibody (CAB1412)
- SKU:
- CAB1412
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | HLA-DPB1 Rabbit Polyclonal Antibody |
SKU: | CAB1412 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-225 of human HLA-DPB1 (NP_002112.3). |
Sequence: | RATP ENYL FQGR QECY AFNG TQRF LERY IYNR EEFA RFDS DVGE FRAV TELG RPAA EYWN SQKD ILEE KRAV PDRM CRHN YELG GPMT LQRR VQPR VNVS PSKK GPLQ HHNL LVCH VTDF YPGS IQVR WFLN GQEE TAGV VSTN LIRN GDWT FQIL VMLE MTPQ QGDV YTCQ VEHT SLDS PVTV EWKA QSDS ARSK |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | DPB1; HLA-DP; HLA-DPB; HLA-DP1B; HLA-DPB1 |
Positive Sample: | Raji |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Endoplasmic reticulum membrane, Endosome membrane, Golgi apparatus, Lysosome membrane, Single-pass type I membrane protein, trans-Golgi network membrane. |
Calculated MW: | 29kDa |
Observed MW: | 25-35kDa |
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Purification Method: | Affinity purification |
Gene ID: | 3115 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |