HLA-DMA Rabbit Polyclonal Antibody (CAB6922)
- SKU:
- CAB6922
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | HLA-DMA Rabbit Polyclonal Antibody |
SKU: | CAB6922 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-233 of human HLA-DMA (NP_006111.2). |
Sequence: | VPEA PTPM WPDD LQNH TFLH TVYC QDGS PSVG LSEA YDED QLFF FDFS QNTR VPRL PEFA DWAQ EQGD APAI LFDK EFCE WMIQ QIGP KLDG KIPV SRGF PIAE VFTL KPLE FGKP NTLV CFVS NLFP PMLT VNWQ HHSV PVEG FGPT FVSA VDGL SFQA FSYL NFTP EPSD IFSC IVTH EIDR YTAI AYWV PRNA LPSD LLEN VLC |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | DMA; HLADM; RING6; D6S222E; HLA-DMA |
Positive Sample: | A-431,Jurkat,HeLa,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein. |
Calculated MW: | 29kDa |
Observed MW: | 35kDa |
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Purification Method: | Affinity purification |
Gene ID: | 3108 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |