The HLA-B Antibody (PAC054122) is a crucial tool for researchers studying the human leukocyte antigen (HLA) system, which plays a key role in immune response and transplant compatibility. This polyclonal antibody, produced in rabbits, is highly specific to HLA-B antigens in human samples and has been validated for use in various applications, including immunohistochemistry and flow cytometry.HLA-B is a major histocompatibility complex (MHC) class I molecule that presents antigens to T cells, playing a critical role in immune recognition and response. Research on HLA-B is vital for understanding immune-mediated diseases, such as autoimmune disorders and infectious diseases, as well as for improving organ transplant outcomes by matching donor and recipient HLA types.
By utilizing the HLA-B Antibody, researchers can accurately detect and analyze HLA-B expression in different cell types and tissues, providing valuable insights into immune system function and disease pathogenesis. This antibody is a valuable tool for advancing immunology research and developing new strategies for treating immune-related disorders.
Western Blot. Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate. All lanes: HLA-B antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 41 kDa. Observed band size: 41 kDa.
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO54122 at dilution of 1:100.
Background:
Involved in the presentation of foreign antigens to the immune system.
Synonyms:
HLA class I histocompatibility antigen, B-82 α chain (MHC class I antigen B*82), HLA-B, HLAB
UniProt Protein Function:
Involved in the presentation of foreign antigens to the immune system.
UniProt Protein Details:
NCBI Summary:
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
