The HLA-A Antibody (PACO07260) is a highly specific tool for research into the HLA-A protein, a key player in the immune system's recognition of foreign antigens. This polyclonal antibody, generated in rabbits, is optimized for use in various applications, including Western blotting and immunohistochemistry. It binds specifically to the HLA-A protein, enabling accurate detection and analysis in human samples.HLA-A, also known as human leukocyte antigen-A, plays a crucial role in presenting antigens to T cells, thereby initiating immune responses against intruders such as viruses, bacteria, and tumor cells.
The HLA-A Antibody is an indispensable tool for studying the function and expression of HLA-A in different cell types, making it a valuable asset in immunology and cancer research.Understanding the role of HLA-A is essential for developing strategies to enhance immune responses against pathogens and cancer cells, as well as for unraveling the mechanisms underlying autoimmune diseases and transplant rejection. The HLA-A Antibody offers researchers a reliable and specific tool to further explore the functions of this important immune regulator.
Antibody Name:
HLA-A Antibody (PACO07260)
Antibody SKU:
PACO07260
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000-1:20000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthetic Peptide of HLA Class I
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
UniProt Protein Function:
Involved in the presentation of foreign antigens to the immune system.
NCBI Summary:
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
