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HK1 Monoclonal Antibody [P4D7AT] (CPAB0134)

SKU:
CPAB0134
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
P4D7AT
Applications:
WB
ELISA
€149

Description

system_update_alt Datasheet

HK1 Monoclonal Antibody [P4D7AT] (CPAB0134)

The HK1 Polyclonal Antibody (CPAB0134) is a crucial tool for researchers studying the expression and function of the HK1 protein. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for various research applications, including Western blotting.HK1, also known as hexokinase-1, is a key enzyme involved in the first step of glycolysis, the metabolic pathway that converts glucose into energy. Dysregulation of HK1 has been linked to various diseases, including cancer and diabetes, making it a promising target for therapeutic interventions.

By using the HK1 Polyclonal Antibody, researchers can accurately detect and analyze HK1 protein levels in different cell types, aiding in the investigation of its role in metabolic processes and disease development. This antibody is a valuable tool for advancing our understanding of HK1 biology and identifying potential targets for novel treatments in metabolic disorders and cancer.

Product Name:HK1 Antibody
Product Sku:CPAB0134
Size:5μg
Host Species:Mouse
Immunogen:Anti-human Hexokinase-1 mAb is derived from hybridization of mouse SP2/ myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Hexokinase-1 amino acids 1-917 purified from Ecoli.
Clone:P4D7AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:Hexokinase-1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2a
Background:Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Hexokinase1 encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of HXK1 results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.
Synonyms:Hexokinase-1, EC 2.7.1.1, Hexokinase type I, HK I, Brain form hexokinase, HK1-ta, HK1-tb, HXK1, HK1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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