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HK1/2/3 Monoclonal Antibody [PAT4C12AT] (CPAB0270)

SKU:
CPAB0270
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1 
Clone:
PAT4C12AT
Applications:
WB
ELISA
€149

Description

system_update_alt Datasheet

HK1/2/3 Monoclonal Antibody [PAT4C12AT] (CPAB0270)

The HK1/2/3 Polyclonal Antibody (CPAB0270) is a valuable tool for researchers studying the hexokinase (HK) protein family, which plays a crucial role in glycolysis, the metabolic pathway that produces energy for cells. This antibody, raised in rabbits, is specifically reactive with HK1/2/3 proteins in human samples and has been validated for use in Western blot applications. By binding to the HK1/2/3 proteins, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in metabolism, cancer research, and drug development.HK enzymes are essential for glucose metabolism, as they catalyze the first step of glycolysis by converting glucose to glucose-6-phosphate.

Dysregulation of HK proteins has been implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders. Therefore, investigating the expression and activity of HK1/2/3 is crucial for understanding these pathologies and developing targeted therapies.By using the HK1/2/3 Polyclonal Antibody, researchers can gain insights into the role of HK enzymes in cellular metabolism and disease progression. This antibody is a valuable tool for advancing our understanding of glycolysis and its implications for human health.

Product Name:HK1/2/3 Antibody
Product Sku:CPAB0270
Size:5μg
Host Species:Mouse
Immunogen:Anti-human HK1/2/3mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HK1/2/3amino acids 1-923 purified from Ecoli.
Clone:PAT4C12AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:HK1/2/3 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1 
Background:Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. HK3 encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. Hexokinase3 lacks the hydrophobic N-terminal sequence critical for targeting to mitochondria. Hexpkinase3 may have anabolic functions, providing H6P for glycogen or lipid synthesis.
Synonyms:Hexokinase-3, EC 2.7.1.1, Hexokinase type III, HK III, HXK3, HK3.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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