HIV Antibodies, Proteins & ELISA Kits

HIV (human immunodeficiency virus) is a virus which is known for attacking the immune system, resulting in the infected individual having a weakened immune response when fighting off infection. In particular, HIV depletes CD4+ T cells in the body. There are two types of HIV which are HIV-1 and HIV-2.

HIV-1 accounts for the vast majority of HIV infections, whereas, HIV-2 is less common and less transmissible. HIV can be transmitted through various routes, some of which are through non protected vaginal and anal sex with a HIV positive person whereby the susceptible individual is not on treatment for preventing transmission and through needle sharing between individuals whereby one person is HIV positive and the other person is not on preventative treatment. Advanced stages of HIV are referred to as AIDS (acquired immunodeficiency syndrome).

In 2018, 38.0 million individuals around the world were living with HIV. HIV cannot be cured, therefore, when someone becomes infected they have it for their entire life. Throughout the years there have been advancements with HIV related treatments such as antiretroviral therapy (ART), however, there are no vaccines developed to prevent HIV at present.

ELISA is used for detecting the presence of HIV for diagnostic purposes and early detection is critical for preventing transmission of the virus.

HIV is associated with chronic activation of the immune system and numerous studies have identified biomarkers which are either depleted or abundant in HIV individuals in comparison to uninfected individuals.

GeniePlex multiplex assays are a bead-based multiplex immunoassay technology that enables the simultaneous & quantitative detection of up to 24 analytes in a single 15ul sample on almost any flow cytometer.

The most commonly used experimental animal models of HIV are mouse and non-human primate models. Assay Genie offers a wide range of animal model ELISA kits with the potential to support the advancing field of HIV research.

Recombinant proteins are useful products which aid in the understanding of viral pathogenesis. Some common HIV recombinant proteins are HIV antigens which aid in viral replication and progression of infection.

Every virus has specific antigens which antibodies can bind to for diagnostic or research purposes. HIV has antigens such as p24 core proteins, gp41, gp32 and gp120 glycoproteins, nef (negative regulating factor) accessory proteins, TAT (transactivator proteins), integrases and proteases.

• Mechanisms of HIV persistence during HAART