The Histone H2B Antibody (PACO02981) is a polyclonal antibody specifically designed for research involving histone H2B, a key protein component of chromatin structure. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the histone H2B protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in epigenetics and gene regulation.Histone H2B is crucial for packaging DNA into chromatin, playing a fundamental role in gene expression and regulation. Research into histone H2B can provide valuable insights into how chromatin structure impacts various cellular processes, including transcription, DNA replication, and DNA repair.
By studying histone H2B, researchers can gain a deeper understanding of epigenetic mechanisms and their implications in development, disease, and therapy.This antibody offers researchers a reliable tool for investigating histone H2B function in various biological contexts, from normal cellular processes to disease states. Its specificity and sensitivity make it an ideal choice for experiments aimed at uncovering the intricate mechanisms governing chromatin dynamics and gene expression. By using the Histone H2B Antibody (PACO02981), scientists can advance our knowledge of epigenetic regulation and potentially uncover new therapeutic targets for a range of diseases.
Antibody Name:
Histone H2B Antibody
Antibody SKU:
PACO02981
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from human Histone H2B around the non-acetylation site of K15.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
H2BFS; Histone H2B type F-S; Histone H2B.s; H2B/s
UniProt Protein Function:
H2BFS: a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 21q22.3Cellular Component: cytoplasm; extracellular space; nucleoplasm; nucleusMolecular Function: DNA binding; protein heterodimerization activityBiological Process: antibacterial humoral response; defense response to Gram-positive bacterium; innate immune response in mucosa; nucleosome assembly; substantia nigra development
