The Histone H1.0 Polyclonal Antibody (CAB6918) is a valuable tool for researchers studying histone H1.0, a protein involved in chromatin structure and gene regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.Histone H1.0 is a member of the histone H1 family, which plays a crucial role in maintaining chromatin structure and compactness. It has been implicated in gene regulation, DNA replication, and genome stability. By binding specifically to histone H1.
0, this antibody enables precise detection and analysis of this protein in various cell types.Research involving histone H1.0 is important for understanding epigenetic mechanisms that regulate gene expression and chromatin organization. Dysregulation of histone H1.0 has been associated with various human diseases, including cancer and neurological disorders. Therefore, this antibody serves as a valuable tool for investigations in the fields of epigenetics, cancer biology, and developmental biology.
Product Name:
Histone H1.0 Rabbit Polyclonal Antibody
SKU:
CAB6918
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human H1F0 (NP_005309.1).
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family.
Purification Method:
Affinity purification
Gene ID:
3005
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Histone H1.0 antibody (CAB6918) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
