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HIST3H2A Antibody (PACO09732)

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SKU:
PACO09732
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€669

Description

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HIST3H2A Antibody (PACO09732)

The Hist3H2A Polyclonal Antibody (PACO09732) is a valuable tool for researchers studying Hist3H2A, a histone protein that plays a crucial role in chromatin structure and gene regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the Hist3H2A protein, allowing for accurate detection and analysis in a variety of cell types.Hist3H2A is known for its involvement in epigenetic regulation and its alteration has been linked to various diseases, including cancer and neurological disorders.

By understanding the function and expression of Hist3H2A, researchers can gain insight into the mechanisms underlying these conditions and potentially identify new therapeutic targets. The Hist3H2A Polyclonal Antibody is a valuable tool for investigating the role of Hist3H2A in these disease processes and advancing our understanding of epigenetic regulation.

Antibody Name:HIST3H2A Antibody (PACO09732)
Antibody SKU:PACO09732
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human HIST3H2A
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:histone cluster 3, H2a;HIST3H2A;MGC3165 ;
UniProt Protein Function:HIST3H2A: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 1q42.13

Molecular Function:DNA binding

Biological Process: chromatin silencing; nucleosome disassembly

NCBI Summary:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
UniProt Code:Q7L7L0
NCBI GenInfo Identifier:74749897
NCBI Gene ID:92815
NCBI Accession:Q7L7L0.3
UniProt Secondary Accession:Q7L7L0,B2R4S4,
UniProt Related Accession:Q7L7L0
Molecular Weight:14,121 Da
NCBI Full Name:Histone H2A type 3
NCBI Synonym Full Names:histone cluster 3, H2a
NCBI Official Symbol:HIST3H2A  
NCBI Protein Information:histone H2A type 3
UniProt Protein Name:Histone H2A type 3
Protein Family:Histone
UniProt Gene Name:HIST3H2A  
UniProt Entry Name:H2A3_HUMAN

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