The HIST1H2BM Polyclonal Antibody (PAC027373) is a valuable tool for researchers studying histone proteins and their role in chromatin structure and gene regulation. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. It targets the HIST1H2BM protein, enabling accurate detection and analysis in various cell types, making it ideal for investigations in epigenetics and gene expression studies.Histone proteins, such as HIST1H2BM, play a crucial role in packaging DNA into chromatin and regulating gene expression.
Understanding the functions of specific histone variants can provide insight into various biological processes, including DNA replication, repair, and transcription. The HIST1H2BM antibody is a valuable tool for researchers exploring the complexities of chromatin biology and gene regulation, offering new opportunities for advancing our knowledge in molecular biology and disease mechanisms.
Antibody Name:
Hist1h2bm Antibody (PACO27373)
Antibody SKU:
PACO27373
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Histone H2B type 1-M protein (2-126AA)
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Synonyms:
Histone H2B type 1-M (H2B 291B), Hist1h2bm
UniProt Protein Function:
H2B1D: a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Interacts with acetylated H4 during chromatin remodeling. Binds to HIRA, a replication-dependent histone family member.Protein type: DNA-bindingCellular Component: chromosome; cytoplasm; nucleoplasm; nucleosome; nucleusMolecular Function: DNA binding; protein heterodimerization activityBiological Process: nucleosome assembly
UniProt Protein Details:
NCBI Summary:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
