The Hist1H1T Polyclonal Antibody (CAB18597) is a valuable tool for researchers studying Hist1H1T, a member of the histone H1 protein family that plays a crucial role in chromatin structure and gene regulation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.Hist1H1T is involved in the organization of DNA into chromatin, impacting gene expression and cell differentiation. Dysregulation of histone proteins like Hist1H1T has been linked to various diseases, including cancer and neurodegenerative disorders.
By targeting Hist1H1T, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.This antibody allows for the detection and analysis of Hist1H1T in different cell types, providing researchers with a powerful tool for investigating the role of histone proteins in disease development and progression. Its high specificity and sensitivity make it an ideal choice for studies in molecular biology, epigenetics, and cancer research.
Product Name:
Histone H1t Rabbit Polyclonal Antibody
SKU:
CAB18597
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 110-209 of mouse Histone H1t (NP_034507.2).
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element
Purification Method:
Affinity purification
Gene ID:
107970
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Histone H1t Rabbit pAb (CAB18597) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
