HIST1H1D (Ab-140) Antibody (PACO56639)
- SKU:
- PACO56639
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
HIST1H1D (Ab-140) Antibody (PACO56639)
The Hist1h1D Antibody (PACO56639) is a valuable tool for researchers studying the histone cluster 1, H1d (HIST1H1D) protein in various cellular processes. This polyclonal antibody, produced in rabbits, shows high specificity and reactivity with human samples, making it ideal for use in immunohistochemistry, Western blot, and other experimental applications.Histone cluster 1, H1d is a member of the histone H1 family, playing a crucial role in chromatin organization and gene regulation. Aberrant expression or function of HIST1H1D has been linked to various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions.
By using the Hist1h1D Antibody (PACO56639), researchers can accurately detect and analyze the expression of HIST1H1D in different cell types and tissues, providing insights into its biological functions and potential implications in disease pathology. This antibody is a valuable asset for studies in epigenetics, cancer biology, and other fields where histone proteins are of interest.
| Antibody Name: | HIST1H1D (Ab-140) Antibody (PACO56639) |
| Antibody SKU: | PACO56639 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:100-1:1000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Peptide sequence around site of Lys (140) derived from Human Histone H1.3 |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Jurkat whole cell lysate, K562 whole cell lysate, PC-3 whole cell lysate. All lanes: HIST1H1D antibody at 1:166. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 23 kDa. Observed band size: 32 kDa. |
 | Immunofluorescent analysis of Hela cells using PACO56639 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human melanoma using PACO56639 at dilution of 1:100. |
| Background: | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). |
| Synonyms: | Histone H1.3 (Histone H1c) (Histone H1s-2), HIST1H1D, H1F3 |
| UniProt Protein Function: | H1D: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: nuclear chromatin Molecular Function:chromatin DNA binding |
| NCBI Summary: | Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P16402 |
| NCBI GenInfo Identifier: | 121925 |
| NCBI Gene ID: | 3007 |
| NCBI Accession: | P16402.2 |
| UniProt Secondary Accession: | P16402,Q2M2I2, B2R751, |
| UniProt Related Accession: | P16402 |
| Molecular Weight: | 22,350 Da |
| NCBI Full Name: | Histone H1.3 |
| NCBI Synonym Full Names: | histone cluster 1, H1d |
| NCBI Official Symbol: | HIST1H1DÂ Â |
| NCBI Official Synonym Symbols: | H1D; H1.3; H1F3; H1s-2Â Â |
| NCBI Protein Information: | histone H1.3 |
| UniProt Protein Name: | Histone H1.3 |
| UniProt Synonym Protein Names: | Histone H1c; Histone H1s-2 |
| UniProt Gene Name: | HIST1H1DÂ Â |
| UniProt Entry Name: | H13_HUMAN |
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