The Anti-Histone H1.2 Antibody (CAB0646) is a valuable tool for research involving histone H1.2, a key component of chromatin structure and gene expression regulation. This polyclonal antibody, produced in rabbits, is highly specific to human histone H1.2 and has been validated for use in various applications, including Western blotting.Histone H1.2 is essential for maintaining chromatin structure and packaging DNA in the nucleus. Its role in gene expression regulation makes it a crucial player in cell differentiation, development, and disease progression.
The Anti-Histone H1.2 Antibody binds specifically to histone H1.2, allowing for precise detection and analysis in a variety of biological samples.Researchers studying epigenetic mechanisms, gene regulation, and chromatin dynamics will find the Anti-Histone H1.2 Antibody to be an indispensable tool in their studies. By understanding the functions and interactions of histone H1.2, scientists can unravel complex biological processes and potentially uncover new therapeutic targets for a range of diseases, including cancer and neurological disorders.
Product Name:
Histone H1.2 Rabbit Monoclonal Antibody
SKU:
CAB0646
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat,Other (Wide Range Predicted)
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Histone H1.2 (P16403).
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
Purification Method:
Affinity purification
Gene ID:
3006
Clone Number:
ARC1836
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Histone H1.2 Rabbit mAb (CAB0646) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
