HIST1H1B (Ab-66) Antibody (PACO56632)
- SKU:
- PACO56632
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
HIST1H1B (Ab-66) Antibody (PACO56632)
The Hist1H1B AB-66 Antibody (PAC056632) is a polyclonal antibody designed for research involving Histone Cluster 1 H1 Family Member B (Hist1H1B), a protein involved in chromatin structure and gene regulation. This antibody, raised in rabbits, has high reactivity with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.Hist1H1B is a histone protein that plays a crucial role in packaging DNA into chromatin, thereby regulating gene expression. Dysregulation of histone proteins like Hist1H1B has been linked to various diseases, including cancer and developmental disorders.
By targeting Hist1H1B, researchers can study its role in gene regulation and potentially develop therapeutics targeting chromatin remodeling.This antibody allows for the detection and analysis of Hist1H1B in different cell types, making it ideal for studies in epigenetics, cancer research, and developmental biology. Understanding the function of Hist1H1B is essential for unraveling the complexities of gene regulation and its implications for various diseases.
| Antibody Name: | HIST1H1B (Ab-66) Antibody (PACO56632) |
| Antibody SKU: | PACO56632 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Peptide sequence around site of Lys (66) derived from Human Histone H1.5 |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO56632 at dilution of 1:100. |
| Background: | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). |
| Synonyms: | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3), HIST1H1B, H1F5 |
| UniProt Protein Function: | H1B: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p22.1 Cellular Component: nuclear chromatin; nuclear heterochromatin; nucleosome Molecular Function:chromatin DNA binding; histone deacetylase binding Biological Process: establishment and/or maintenance of chromatin architecture; negative regulation of transcription from RNA polymerase II promoter; nucleosome assembly; positive regulation of cell growth; positive regulation of histone H3-K9 methylation; protein stabilization |
| NCBI Summary: | Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P16401 |
| NCBI GenInfo Identifier: | 19856407 |
| NCBI Gene ID: | 3009 |
| NCBI Accession: | P16401.3 |
| UniProt Secondary Accession: | P16401,Q14529, Q3MJ42, |
| UniProt Related Accession: | P16401 |
| Molecular Weight: | 22,580 Da |
| NCBI Full Name: | Histone H1.5 |
| NCBI Synonym Full Names: | histone cluster 1, H1b |
| NCBI Official Symbol: | HIST1H1BÂ Â |
| NCBI Official Synonym Symbols: | H1; H1B; H1.5; H1F5; H1s-3Â Â |
| NCBI Protein Information: | histone H1.5 |
| UniProt Protein Name: | Histone H1.5 |
| UniProt Synonym Protein Names: | Histone H1a; Histone H1b; Histone H1s-3 |
| Protein Family: | Histone |
| UniProt Gene Name: | HIST1H1BÂ Â |
| UniProt Entry Name: | H15_HUMAN |
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