HIST1H1B (Ab-188) Antibody (PACO56610)
- SKU:
- PACO56610
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
HIST1H1B (Ab-188) Antibody (PACO56610)
The Hist1H1B Polyclonal Antibody (PACO56610) is a valuable tool for researchers studying the Hist1H1B protein, which plays a crucial role in chromatin structure and gene regulation. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.Hist1H1B is a member of the histone H1 family, which is involved in the organization and compaction of chromatin. It is essential for the regulation of gene expression and plays a role in various cellular processes, including DNA replication and repair. The Hist1H1B Polyclonal Antibody binds specifically to Hist1H1B protein, allowing researchers to study its expression and function in different cell types.
With its high reactivity and specificity, the Hist1H1B Polyclonal Antibody is an ideal tool for studies in epigenetics, gene regulation, and chromatin biology. By understanding the role of Hist1H1B in these processes, researchers can gain insights into various diseases, including cancer, developmental disorders, and neurodegenerative diseases. This antibody is a valuable resource for scientists looking to uncover the mechanisms underlying chromatin dynamics and gene expression regulation.
| Antibody Name: | HIST1H1B (Ab-188) Antibody (PACO56610) |
| Antibody SKU: | PACO56610 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:100-1:1000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Peptide sequence around site of Ser (188) derived from Human Histone H1.5 |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: MCF-7 whole cell lysate, U87 whole cell lysate. All lanes: HIST1H1B antibody at 1.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 23 kDa. Observed band size: 23 kDa. |
 | Immunohistochemistry of paraffin-embedded human melanoma using PACO56610 at dilution of 1:100. |
| Background: | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). |
| Synonyms: | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3), HIST1H1B, H1F5 |
| UniProt Protein Function: | H1B: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p22.1 Cellular Component: nuclear chromatin; nuclear heterochromatin; nucleosome Molecular Function:chromatin DNA binding; histone deacetylase binding Biological Process: establishment and/or maintenance of chromatin architecture; negative regulation of transcription from RNA polymerase II promoter; nucleosome assembly; positive regulation of cell growth; positive regulation of histone H3-K9 methylation; protein stabilization |
| NCBI Summary: | Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P16401 |
| NCBI GenInfo Identifier: | 19856407 |
| NCBI Gene ID: | 3009 |
| NCBI Accession: | P16401.3 |
| UniProt Secondary Accession: | P16401,Q14529, Q3MJ42, |
| UniProt Related Accession: | P16401 |
| Molecular Weight: | 22,580 Da |
| NCBI Full Name: | Histone H1.5 |
| NCBI Synonym Full Names: | histone cluster 1, H1b |
| NCBI Official Symbol: | HIST1H1BÂ Â |
| NCBI Official Synonym Symbols: | H1; H1B; H1.5; H1F5; H1s-3Â Â |
| NCBI Protein Information: | histone H1.5 |
| UniProt Protein Name: | Histone H1.5 |
| UniProt Synonym Protein Names: | Histone H1a; Histone H1b; Histone H1s-3 |
| Protein Family: | Histone |
| UniProt Gene Name: | HIST1H1BÂ Â |
| UniProt Entry Name: | H15_HUMAN |
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