HIST1H1B (Ab-154) Antibody (PACO56602)
- SKU:
- PACO56602
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
HIST1H1B (Ab-154) Antibody (PACO56602)
The HIST1H1B Monoclonal Antibody (PACO56602) is a powerful tool for research involving histone proteins, specifically HIST1H1B. This antibody, produced in a monoclonal format, demonstrates high specificity and sensitivity in detecting HIST1H1B in human samples, making it an essential tool for histone research.Histone proteins play a vital role in gene regulation and chromatin structure, with HIST1H1B being involved in nucleosome formation and chromatin compaction. The HIST1H1B Monoclonal Antibody is validated for use in various applications, including Western blot and immunohistochemistry, allowing for detailed analysis of HIST1H1B expression and localization in different cell types and tissues.
With its ability to bind specifically to HIST1H1B, this antibody enables researchers to investigate the role of histone proteins in gene expression, DNA replication, and epigenetic regulation. Its versatility and reliability make it an invaluable tool for studies in molecular biology, epigenetics, and cancer research, providing key insights into the intricate mechanisms of gene regulation and chromatin dynamics.
| Antibody Name: | HIST1H1B (Ab-154) Antibody (PACO56602) |
| Antibody SKU: | PACO56602 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Peptide sequence around site of Thr (154) derived from Human Histone H1.5 |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO56602 at dilution of 1:100. |
| Background: | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). |
| Synonyms: | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3), HIST1H1B, H1F5 |
| UniProt Protein Function: | H1B: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p22.1 Cellular Component: nuclear chromatin; nuclear heterochromatin; nucleosome Molecular Function:chromatin DNA binding; histone deacetylase binding Biological Process: establishment and/or maintenance of chromatin architecture; negative regulation of transcription from RNA polymerase II promoter; nucleosome assembly; positive regulation of cell growth; positive regulation of histone H3-K9 methylation; protein stabilization |
| NCBI Summary: | Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P16401 |
| NCBI GenInfo Identifier: | 19856407 |
| NCBI Gene ID: | 3009 |
| NCBI Accession: | P16401.3 |
| UniProt Secondary Accession: | P16401,Q14529, Q3MJ42, |
| UniProt Related Accession: | P16401 |
| Molecular Weight: | 22,580 Da |
| NCBI Full Name: | Histone H1.5 |
| NCBI Synonym Full Names: | histone cluster 1, H1b |
| NCBI Official Symbol: | HIST1H1BÂ Â |
| NCBI Official Synonym Symbols: | H1; H1B; H1.5; H1F5; H1s-3Â Â |
| NCBI Protein Information: | histone H1.5 |
| UniProt Protein Name: | Histone H1.5 |
| UniProt Synonym Protein Names: | Histone H1a; Histone H1b; Histone H1s-3 |
| Protein Family: | Histone |
| UniProt Gene Name: | HIST1H1BÂ Â |
| UniProt Entry Name: | H15_HUMAN |
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