HIRA Rabbit Polyclonal Antibody (CAB12527)
- SKU:
- CAB12527
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | HIRA Rabbit Polyclonal Antibody |
SKU: | CAB12527 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-550 of human HIRA (NP_003316.3). |
Sequence: | AQII EREG WKTN MDFV GHRK AVTV VKFN PKIF KKKQ KNGS SAKP SCPY CCCA VGSK DRSL SVWL TCLK RPLV VIHE LFDK SIMD ISWT LNGL GILV CSMD GSVA FLDF SQDE LGDP LSEE EKSR IHQS TYGK SLAI MTEA QLST AVIE NPEM LKYQ RRQQ QQQL DQKS AATR EMGS ATSV AGVV NGES LEDI RKNL LKKQ VETR TADG RRRI TPLC IAQL DTGD FSTA FFNS IPLS GSLA GTML SSHS SPQL LPLD SSTP NSFG ASKP CTEP VVAA SARP AGDS VNKD SMNA TSTP AALS P |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | TUP1; DGCR1; TUPLE1; HIRA |
Positive Sample: | HepG2,HeLa,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus, PML body. |
Calculated MW: | 112kDa |
Observed MW: | 112kDa |
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Purification Method: | Affinity purification |
Gene ID: | 7290 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |