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HIPK4 Antibody (PACO15651)

SKU:
PACO15651
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • HIPK4 Antibody PACO15651
  • HIPK4 Antibody PACO15651
€339

Description

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HIPK4 Antibody (PACO15651)

The HIPK4 Polyclonal Antibody (PAC015651) is a valuable tool for researchers studying the HIPK4 protein, a key regulator of cell proliferation and apoptosis. This antibody, developed using rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the HIPK4 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential component for research in cell biology and cancer.HIPK4, also known as homeodomain-interacting protein kinase 4, plays a crucial role in a variety of cellular processes, including DNA damage response and gene regulation.

Its involvement in cell growth and survival pathways makes it a promising target for studies on cancer development and progression. Understanding the function of HIPK4 is essential for advancing knowledge on the molecular mechanisms underlying cancer and for identifying potential therapeutic strategies targeting this protein.

Antibody Name:HIPK4 Antibody (PACO15651)
Antibody SKU:PACO15651
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:Human, Mouse, Rat
Immunogen:Fusion protein of human HIPK4
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15651(HIPK4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO15651(HIPK4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:HIPK4 (Homeodomain-interacting protein kinase 4) is a 616 amino acid, protein that localizes to the cytoplasm and exists as two isoforms that are produced by alternative splicing events. Like other members of the HIPK family, HIPK4 functions as a protein kinase that catalyzes the ATP-dependent phosphorylation of target proteins and is thought to act as a corepressor of target transcription factors.
Synonyms:homeodomain interacting protein kinase 4
UniProt Protein Function:HIPK4: a CMGC kinase of the DYRK family.Protein type: EC 2.7.11.1; Protein kinase, CMGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; DYRK family; HIPK subfamilyChromosomal Location of Human Ortholog: 19q13.2Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016]
UniProt Code:Q8NE63
NCBI GenInfo Identifier:74762559
NCBI Gene ID:147746
NCBI Accession:Q8NE63.1
UniProt Secondary Accession:Q8NE63,Q96M54, A8K863
UniProt Related Accession:Q8NE63
Molecular Weight:69,425 Da
NCBI Full Name:Homeodomain-interacting protein kinase 4
NCBI Synonym Full Names:homeodomain interacting protein kinase 4
NCBI Official Symbol:HIPK4  
NCBI Official Synonym Symbols:
NCBI Protein Information:homeodomain-interacting protein kinase 4
UniProt Protein Name:Homeodomain-interacting protein kinase 4
UniProt Synonym Protein Names:
Protein Family:Homeodomain-interacting protein kinase
UniProt Gene Name:HIPK4  
UniProt Entry Name:HIPK4_HUMAN
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