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HIPK4 Antibody (PACO15650)

SKU:
PACO15650
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

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HIPK4 Antibody (PACO15650)

The HIPK4 Polyclonal Antibody (PAC015650) is a valuable tool for researchers studying the HIPK4 protein, which is involved in cellular processes related to cancer progression and immune regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically recognizing and binding to the HIPK4 protein, this antibody enables accurate detection and analysis in a variety of cell types.HIPK4 is a critical player in cell signaling pathways that impact cell growth, differentiation, and survival, making it a key target for investigations in cancer biology and immunology.

Research on the function and regulation of HIPK4 could provide insights into potential therapeutic strategies for cancer treatment and immune-related disorders. By using the HIPK4 Polyclonal Antibody, scientists can further unravel the complex mechanisms involving HIPK4 and its role in disease pathogenesis.

Antibody Name:HIPK4 Antibody (PACO15650)
Antibody SKU:PACO15650
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:Human, Mouse, Rat
Immunogen:Fusion protein of human HIPK4
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15650(HIPK4 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:HIPK4 (Homeodomain-interacting protein kinase 4) is a 616 amino acid, protein that localizes to the cytoplasm and exists as two isoforms that are produced by alternative splicing events. Like other members of the HIPK family, HIPK4 functions as a protein kinase that catalyzes the ATP-dependent phosphorylation of target proteins and is thought to act as a corepressor of target transcription factors.
Synonyms:homeodomain interacting protein kinase 4
UniProt Protein Function:HIPK4: a CMGC kinase of the DYRK family.Protein type: EC 2.7.11.1; Protein kinase, CMGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; DYRK family; HIPK subfamilyChromosomal Location of Human Ortholog: 19q13.2Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016]
UniProt Code:Q8NE63
NCBI GenInfo Identifier:74762559
NCBI Gene ID:147746
NCBI Accession:Q8NE63.1
UniProt Secondary Accession:Q8NE63,Q96M54, A8K863
UniProt Related Accession:Q8NE63
Molecular Weight:69,425 Da
NCBI Full Name:Homeodomain-interacting protein kinase 4
NCBI Synonym Full Names:homeodomain interacting protein kinase 4
NCBI Official Symbol:HIPK4  
NCBI Official Synonym Symbols:
NCBI Protein Information:homeodomain-interacting protein kinase 4
UniProt Protein Name:Homeodomain-interacting protein kinase 4
UniProt Synonym Protein Names:
Protein Family:Homeodomain-interacting protein kinase
UniProt Gene Name:HIPK4  
UniProt Entry Name:HIPK4_HUMAN
Antibodies
HIPK4 Antibody (PACO00906)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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