The HIC1 Polyclonal Antibody (CAB9651) is a valuable tool for research focused on the HIC1 protein, a tumor suppressor involved in regulating cell growth and apoptosis. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the HIC1 protein, researchers can accurately detect and analyze its expression in various cell types, making it an ideal tool for studies in cancer biology and epigenetics.
HIC1, also known as Hypermethylated in Cancer 1, plays a crucial role in controlling cell proliferation and differentiation, making it a key player in tumor suppression mechanisms. Understanding the functions and regulation of HIC1 is essential for unraveling its contributions to cancer development and progression. This antibody provides researchers with the means to investigate the role of HIC1 in cancer pathways, potentially leading to new insights and therapeutic strategies for cancer treatment.
Product Name:
HIC1 Rabbit Polyclonal Antibody
SKU:
CAB9651
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 180-430 of human HIC1 (NP_001091672.1).
This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3090
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HIC1 Rabbit pAb (CAB9651) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
