The HIC1 Polyclonal Antibody (CAB13907) is a valuable tool for researchers studying the HIC1 protein, a transcriptional repressor involved in tumor suppression and DNA repair. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the HIC1 protein, this antibody allows for the detection and analysis of HIC1 expression in various cell types, making it ideal for studies in cancer biology and genomics.HIC1, also known as Hypermethylated in Cancer 1, is a critical regulator of cell growth and differentiation, playing a key role in maintaining genomic stability and preventing tumorigenesis.
Its dysregulation has been linked to various types of cancer, making it a promising target for cancer therapy and biomarker development. By studying the function of HIC1 using this antibody, researchers can gain valuable insights into the mechanisms underlying cancer development and progression, paving the way for novel therapeutic strategies.
Product Name:
HIC1 Rabbit Polyclonal Antibody
SKU:
CAB13907
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 180-430 of human HIC1 (NP_001091672.1).
This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3090
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse liver, using HIC1 Rabbit pAb (CAB13907) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
