The HGS Polyclonal Antibody (CAB1790) is a powerful research tool specifically designed for studying the HGS protein, a key player in various cellular processes. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the HGS protein, this antibody allows for easy and accurate detection and analysis in a wide range of cell types.The HGS protein, also known as Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate, is involved in intracellular trafficking pathways and plays a crucial role in regulating cellular signaling and protein degradation.
Its function in cell growth, differentiation, and survival makes it an important target for research in areas such as cancer, metabolic disorders, and neurodegenerative diseases.By using the HGS Polyclonal Antibody, researchers can gain insights into the mechanisms by which HGS functions and its impact on various cellular processes. This antibody is a valuable tool for studies in cell biology, molecular biology, and disease research, providing a deeper understanding of HGS and its potential as a therapeutic target.
Product Name:
HGS Rabbit Polyclonal Antibody
SKU:
CAB1790
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 548-777 of human HGS (NP_004703.1).
WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
HRS; HGS
Positive Sample:
THP-1,OVCAR3,MCF7,HepG2,Mouse testis,Rat testis
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Cytoplasmic side, Early endosome membrane, Endosome, Peripheral membrane protein, multivesicular body membrane.
Calculated MW:
86kDa
Observed MW:
110kDa
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.
Purification Method:
Affinity purification
Gene ID:
9146
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HGS Rabbit pAb (CAB1790) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
