The HEYL Polyclonal Antibody (CAB17683) is specifically designed for research involving HEYL, a transcription factor that plays a crucial role in various biological processes, including embryonic development and cell differentiation. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in Western blotting and immunohistochemistry applications. HEYL is known to interact with Notch signaling pathway components and is involved in cell fate determination and tissue morphogenesis. Its dysregulation has been implicated in various diseases, including cancer and cardiovascular disorders, making it a promising target for therapeutic interventions.
By utilizing the HEYL Polyclonal Antibody, researchers can effectively detect and analyze HEYL expression in different cell types and tissues, providing valuable insights into its function and potential implications in various pathological conditions. This antibody is a valuable tool for studies in developmental biology, oncology, and cardiovascular research, contributing to a better understanding of HEYL's role in health and disease.
Product Name:
HEYL Rabbit Polyclonal Antibody
SKU:
CAB17683
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human HEYL (NP_055386.2).
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
26508
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using HEYL Rabbit pAb (CAB17683) at 1:2500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
