The Hexa Polyclonal Antibody (CAB5646) is a valuable tool for researchers studying Hexa, a gene involved in enzyme function and lysosomal storage disorders. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to the Hexa protein, allowing for accurate detection and analysis in a variety of cell types.Hexa is essential for the activity of the enzyme beta-hexosaminidase A, which plays a key role in breaking down certain complex carbohydrates in lysosomes. Mutations in the Hexa gene can lead to lysosomal storage diseases such as Tay-Sachs disease.
By studying the Hexa protein, researchers can gain insights into the molecular mechanisms underlying these disorders and potentially identify new therapeutic targets.The Hexa Polyclonal Antibody is a valuable tool for researchers in the fields of biochemistry, genetics, and neurology who are interested in understanding lysosomal storage disorders and developing treatments for these devastating conditions. Its high specificity and reliability make it an ideal choice for studies investigating the role of Hexa in health and disease.
Product Name:
HEXA Rabbit Polyclonal Antibody
SKU:
CAB5646
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 270-529 of human HEXA (NP_000511.2).
This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
3073
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HEXA antibody (CAB5646) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
