The Hexa Polyclonal Antibody (CAB12443) is a powerful tool for research involving the Hexa gene, which encodes for the alpha subunit of beta-hexosaminidase, a lysosomal enzyme involved in the breakdown of glycosphingolipids. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in various applications such as immunohistochemistry and flow cytometry.The Hexa Polyclonal Antibody (CAB12443) binds specifically to the Hexa protein, allowing for the detection and analysis of Hexa expression in a variety of cell types.
This makes it an ideal choice for studies in lysosomal storage disorders, neurodegenerative diseases, and developmental biology where Hexa plays a crucial role in cellular function.Understanding the expression and activity of Hexa is vital for unraveling the mechanisms underlying lysosomal storage disorders such as Tay-Sachs disease and Sandhoff disease. By using the Hexa Polyclonal Antibody (CAB12443), researchers can further elucidate the role of Hexa in these diseases and potentially discover new therapeutic targets for treatment.
Product Name:
HEXA Rabbit Polyclonal Antibody
SKU:
CAB12443
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 270-529 of human HEXA (NP_000511.2).
This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
3073
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat brain using HEXA Rabbit pAb (CAB12443) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
