HEXA Rabbit Polyclonal Antibody (CAB12443)
- SKU:
- CAB12443
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | HEXA Rabbit Polyclonal Antibody |
SKU: | CAB12443 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-529 of human HEXA (NP_000511.2). |
Sequence: | IPGL LTPC YSGS EPSG TFGP VNPS LNNT YEFM STFF LEVS SVFP DFYL HLGG DEVD FTCW KSNP EIQD FMRK KGFG EDFK QLES FYIQ TLLD IVSS YGKG YVVW QEVF DNKV KIQP DTII QVWR EDIP VNYM KELE LVTK AGFR ALLS APWY LNRI SYGP DWKD FYIV EPLA FEGT PEQK ALVI GGEA CMWG EYVD NTNL VPRL WPRA GAVA ERLW SNKL TSDL TFAY ERLS HFRC ELLR RGVQ AQPL NVGF CEQE FEQT |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | TSD; HEXA |
Conjugate: | Unconjugated |
Cellular Localization: | Lysosome. |
Calculated MW: | 61kDa |
Observed MW: | Refer to figures |
This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Purification Method: | Affinity purification |
Gene ID: | 3073 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |