The HES1 Polyclonal Antibody (CAB11718) is a valuable tool for researchers studying HES1, a transcription factor involved in cell differentiation and development. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the HES1 protein, this antibody enables the detection and analysis of HES1 expression in a variety of cell types, making it an ideal choice for studies in developmental biology and cancer research.
HES1 is a key regulator of stem cell fate and differentiation, playing a crucial role in embryonic development and tissue regeneration. Dysregulation of HES1 has been implicated in various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions. By investigating the function of HES1, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify novel treatment strategies.
Product Name:
HES1 Rabbit Polyclonal Antibody
SKU:
CAB11718
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 90-165 of human HES1 (NP_005515.1).
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
Purification Method:
Affinity purification
Gene ID:
3280
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using HES1 antibody (CAB11718) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
