HERPUD1 Rabbit Polyclonal Antibody (CAB14097)
- SKU:
- CAB14097
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Product Name: | HERPUD1 Rabbit Polyclonal Antibody |
SKU: | CAB14097 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HERPUD1 (NP_055500.1). |
Sequence: | MESE TEPE PVTL LVKS PNQR HRDL ELSG DRGW SVGH LKAH LSRV YPER PRPE DQRL IYSG KLLL DHQC LRDL LPKQ EKRH VLHL VCNV KSPS KMPE INAK VAES TEEP AGSN RGQY PEDS SSDG LRQR EVLR NLSS PGWE NISR PEAA QQAF QGLG PGFS GYTP YGWL QLSW FQQI YARQ YYMQ YLAA TAAS GAFV PPPS AQEI PVVS APAP APIH NQFP AENQ PANQ NAAP QVVV NPGA |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | SUP; HERP; Mif1; HERPUD1 |
Positive Sample: | BT-474,HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Multi-pass membrane protein. |
Calculated MW: | 44kDa |
Observed MW: | 44kDa |
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 9709 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |