The Herpud1 Polyclonal Antibody (CAB14097) is a valuable tool for researchers studying the Herpud1 protein, which is involved in endoplasmic reticulum stress response and protein quality control. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is optimized for use in Western blot applications. By specifically binding to Herpud1, this antibody allows for the accurate detection and analysis of the protein in various cell types, making it an essential component for research in the fields of cell biology and protein regulation.Herpud1, also known as ER-resident protein Herp, is a key player in maintaining cellular homeostasis by facilitating the degradation of misfolded proteins and regulating ER stress pathways.
Dysregulation of Herpud1 has been linked to various diseases, including neurodegenerative disorders and metabolic syndromes, making it a promising target for therapeutic interventions. By unraveling the functions of Herpud1, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially develop novel treatment strategies.Overall, the Herpud1 Polyclonal Antibody (CAB14097) offers a reliable and accurate means of studying Herpud1 protein expression and activity, providing researchers with the tools needed to advance our understanding of cellular stress responses and disease pathogenesis.
Product Name:
HERPUD1 Rabbit Polyclonal Antibody
SKU:
CAB14097
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HERPUD1 (NP_055500.1).
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
9709
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HERPUD1 antibody (CAB14097) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
