HERC5 Rabbit Polyclonal Antibody (CAB14889)
- SKU:
- CAB14889
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | HERC5 Rabbit Polyclonal Antibody |
SKU: | CAB14889 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 360-700 of human HERC5 (NP_057407.2). |
Sequence: | ELIM IAGG NQSI LLWI KKEN SYVN LKRT IPTL NEGT VKRW IADV ETKR WQST KREI QEIF SSPA CLTG SFLR KRRT TEMM PVYL DLNK ARNI FKEL TQKD WITN MITT CLKD NLLK RLPF HSPP QEAL EIFF LLPE CPMM HISN NWES LVVP FAKV VCKM SDQS SLVL EEYW ATLQ ESTF SKLV QMFK TAVI CQLD YWDE SAEE NGNV QALL EMLK KLHR VNQV KCQL PESI FQVD ELLH RLNF FVEV CRRY LWKM TVDA SENV QCCV IFSH FPFI FNNL SKIK LLHT DTLL KIES KKHK AYLR SAAI EEER ESEF ALRP TFDL TVRR NHLI EDVL NQLS Q |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CEB1; CEBP1; HERC5 |
Positive Sample: | U-87MG,OVCAR3,HT-1080,Mouse kidney,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, perinuclear region. |
Calculated MW: | 117kDa |
Observed MW: | 117kDa |
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4.
Purification Method: | Affinity purification |
Gene ID: | 51191 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |