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HERC4 Polyclonal Antibody

SKU:
CAB21427
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
Frequently bought together:

Description

HERC4 Polyclonal Antibody (CAB21427)

The HERC4 Polyclonal Antibody is a valuable tool for researchers studying HERC4, a ubiquitin ligase enzyme involved in various cellular processes such as protein degradation and DNA repair. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the HERC4 protein, researchers can detect and analyze its expression in different cell types, making it an ideal choice for studies in molecular biology and cancer research.HERC4 has been shown to play a crucial role in maintaining cellular homeostasis by regulating the turnover of proteins and DNA damage response pathways.

Its involvement in these pathways makes it a promising target for research into diseases such as cancer and neurodegenerative disorders. Understanding the function of HERC4 is essential for developing targeted therapies that can modulate its activity for therapeutic purposes.Overall, the HERC4 Polyclonal Antibody offers researchers a reliable tool for exploring the role of HERC4 in cellular processes and disease pathways, ultimately advancing our understanding of its potential as a therapeutic target.

Product Name:HERC4 Polyclonal Antibody
Product Code:CAB21427
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:2000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Cellular Location:Cytoplasm, cytosol

HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human HERC4 (NP_056416.2).
Sequence:WTVNE ALIQK WLSYP SGRFP VEIAN EIDGT FSSSG CLNGS FLAVS NDDHY RTGTR FSGVD MNAAR LLFHK LIQPD HPQIS QQVAA SLEKN LIPKL TSSLP DVEAL RFYLT LPECP LMSDS NNFTT IAIPF GTALV NLEKA PLKVL ENWWS VLEPP LFLKI VELFK EVVVH LLKLY KIGIP PSERR IFNSF LHTAL KVLEI LHRVN EKMGQ IIQYD KFYIH EVQEL IDIRN DYINW VQQQA YGMLA DIPVT ICTYP FVFDA QAKTT LLQTD AVLQM QMAID QAHRQ NVSSL FLPVI ESVNP C
Synonyms:HERC4, probable E3 ubiquitin-protein ligase HERC4
Calculated MW:119kDa
Observed MW:Refer to figures

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