The HERC3 Polyclonal Antibody (CAB8567) is a cutting-edge research tool designed for the study of HERC3, a protein with important roles in cellular processes like protein degradation and DNA damage repair. This high-quality antibody, generated in rabbits, demonstrates exceptional reactivity with HERC3 in human samples and has been rigorously validated for Western blot applications.HERC3 is a vital component of the ubiquitin-proteasome system, a key pathway for protein degradation within cells. Dysregulation of this system has been linked to various diseases, including cancer and neurodegenerative disorders.
By targeting HERC3, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.By utilizing the HERC3 Polyclonal Antibody, researchers can confidently detect and analyze HERC3 protein levels in a variety of cell types, aiding in the investigation of its functions and protein interactions. This antibody is an invaluable tool for studies in molecular biology, cancer research, and drug discovery, providing critical information for advancing our understanding of cellular pathways and disease mechanisms.
Product Name:
HERC3 Rabbit Polyclonal Antibody
SKU:
CAB8567
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human HERC3 (NP_055421.1).
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
8916
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HERC3 antibody (CAB8567) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
