The Heparanase Polyclonal Antibody (CAB5726) is a powerful tool for researchers studying heparanase, an enzyme involved in the breakdown of heparan sulfate in the extracellular matrix. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in a variety of applications, including Western blot and immunohistochemistry.Heparanase is known to play a crucial role in various physiological and pathological processes, including cell migration, angiogenesis, inflammation, and cancer metastasis.
By targeting heparanase with this polyclonal antibody, researchers can gain valuable insights into the mechanisms underlying these processes and potentially identify new therapeutic targets for diseases such as cancer and inflammation.With its high specificity and sensitivity, the Heparanase Polyclonal Antibody (CAB5726) is a valuable tool for researchers seeking to unravel the complexities of heparanase biology and its role in human health and disease.
Product Name:
Heparanase 1 Rabbit Polyclonal Antibody
SKU:
CAB5726
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 36-275 of human Heparanase 1 (NP_001092010.1).
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10855
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Heparanase 1 antibody (CAB5726) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
