The HepaCAM Polyclonal Antibody (CAB11589) is a key tool for researchers studying HepaCAM, a cell adhesion molecule associated with hepatocellular carcinoma. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the HepaCAM protein, this antibody allows for accurate detection and analysis in various cell types, making it an essential resource for studies in cancer biology and liver disease research.HepaCAM plays a crucial role in cell adhesion and migration, making it a significant factor in tumor progression and metastasis, particularly in liver cancer.
Understanding the function and expression of HepaCAM is essential for uncovering potential therapeutic targets and biomarkers for hepatocellular carcinoma. The HepaCAM Polyclonal Antibody is a valuable tool for researchers seeking to deepen their understanding of the molecular mechanisms underlying liver cancer and develop innovative treatments for this deadly disease.
Product Name:
HEPACAM Rabbit Polyclonal Antibody
SKU:
CAB11589
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 35-245 of human HEPACAM (NP_689935.2).
Cytoplasm, Cytoplasmic side, Membrane, Single-pass type I membrane protein.
Calculated MW:
46kDa
Observed MW:
70kDa
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.
Purification Method:
Affinity purification
Gene ID:
220296
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HEPACAM Rabbit pAb (CAB11589) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
