HFE2 Rabbit Polyclonal Antibody (CAB5348)
- SKU:
- CAB5348
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | HFE2 Rabbit Polyclonal Antibody |
SKU: | CAB5348 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human HFE2 (NP_998817.1). |
Sequence: | MQEC IDQK VYQA EVDN LPVA FEDG SING GDRP GGSS LSIQ TANP GNHV EIQA AYIG TTII IRQT AGQL SFSI KVAE DVAM AFSA EQDL QLCV GGCP PSQR LSRS ERNR RGAI TIDT ARRL CKEG LPVE DAYF HSCV FDVL ISGD PNFT VAAQ AALE DARA FLPD LEKL HLFP SD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | JH; HFE2; RGMC; HFE2A |
Positive Sample: | Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, GPI-anchor, Lipid-anchor. |
Calculated MW: | 45kDa |
Observed MW: | 52kDa |
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Purification Method: | Affinity purification |
Gene ID: | 148738 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |