The Hemojuvelin Polyclonal Antibody (CAB5348) is a powerful tool for researchers studying the protein hemojuvelin, which is involved in the regulation of iron metabolism and plays a key role in the development of hereditary hemochromatosis, a disorder characterized by excess iron absorption. This antibody, produced in rabbits, has high specificity and sensitivity for detecting hemojuvelin in human samples, making it an invaluable asset for Western blot applications.Hemojuvelin is essential for the control of iron levels in the body and its dysregulation can lead to severe health issues such as organ damage and cardiovascular complications.
By using the Hemojuvelin Polyclonal Antibody, researchers can gain insights into the function and expression of hemojuvelin in various tissues and cell types, paving the way for a better understanding of iron metabolism disorders and the development of potential treatments.Overall, the Hemojuvelin Polyclonal Antibody is a valuable tool for researchers interested in unraveling the complexities of iron metabolism and its relationship to human health, making it an essential component for studies in biology, medicine, and related fields.
Product Name:
HFE2 Rabbit Polyclonal Antibody
SKU:
CAB5348
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human HFE2 (NP_998817.1).
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Purification Method:
Affinity purification
Gene ID:
148738
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat heart, using HFE2 Rabbit pAb (CAB5348) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
