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HELZ2 Antibody (PACO22495)

SKU:
PACO22495
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€419

Description

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HELZ2 Antibody (PACO22495)

The HELZ2 Monoclonal Antibody (PAC022495) is a cutting-edge tool for researchers studying the HELZ2 protein, which plays a crucial role in various cellular processes, including gene expression regulation and DNA repair. This antibody, produced using state-of-the-art technology, specifically targets the HELZ2 protein in human samples, enabling precise detection and analysis in applications such as Western blotting and immunofluorescence.HELZ2, also known as DNA-binding protein AEN, is a key player in maintaining genomic stability and controlling cell proliferation.

Its involvement in DNA damage response pathways makes it a compelling target for investigations into cancer development and therapy resistance mechanisms. By elucidating the functions of HELZ2, researchers can uncover novel strategies for treating cancer and other diseases linked to DNA damage and repair dysregulation.

Antibody Name:HELZ2 Antibody (PACO22495)
Antibody SKU:PACO22495
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:Human
Immunogen:Synthesized peptide derived from internal of human PRIC285.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from Jurkat cells, using PRIC285 antibody.
Background:Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA.
Synonyms:Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein; ATP-dependent helicase PRIC285; PPAR-alpha-interacting complex protein 285; PPAR-gamma DNA-binding domain-interacting protein 1; PPAR-gamma DBD-interacting protein 1
UniProt Protein Function:PRIC285: Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. Belongs to the DNA2/NAM7 helicase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: C2H2-type zinc finger protein; EC 3.6.4.-; Transcription, coactivator/corepressor; Nuclear receptor co-regulator; EC 3.6.1.-; HelicaseChromosomal Location of Human Ortholog: 20q13.33Cellular Component: nucleoplasm; membraneMolecular Function: protein binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; helicase activity; ATP bindingBiological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BYK8
NCBI GenInfo Identifier:156105693
NCBI Gene ID:85441
NCBI Accession:NP_001032412.2
UniProt Secondary Accession:Q9BYK8,Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094
UniProt Related Accession:Q9BYK8
Molecular Weight:294,651 Da
NCBI Full Name:helicase with zinc finger domain 2 isoform 1
NCBI Synonym Full Names:helicase with zinc finger 2, transcriptional coactivator
NCBI Official Symbol:HELZ2  
NCBI Official Synonym Symbols:PDIP-1; PRIC285  
NCBI Protein Information:helicase with zinc finger domain 2; PDIP1; PRIC complex; ATP-dependent helicase PRIC285; PPARG-DBD-interacting protein 1; PPAR gamma DBD-interacting protein 1; PPAR-gamma DBD-interacting protein 1; PPAR-alpha-interacting complex protein 285; PPARgamma-DNA
UniProt Protein Name:Helicase with zinc finger domain 2
UniProt Synonym Protein Names:ATP-dependent helicase PRIC285; Helicase with zinc finger 2, transcriptional coactivator; PPAR-alpha-interacting complex protein 285; PPAR-gamma DNA-binding domain-interacting protein 1; PDIP1; PPAR-gamma DBD-interacting protein 1; Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein
Protein Family:Helicase with zinc finger domain
UniProt Gene Name:HELZ2  
UniProt Entry Name:HELZ2_HUMAN
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