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HELZ2 Antibody (PACO05571)

SKU:
PACO05571
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323

Description

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HELZ2 Antibody (PACO05571)

The HELZ2 Polyclonal Antibody (PACO05571) is a valuable tool for researchers studying the HELZ2 protein, a key regulator of gene expression and cell proliferation. This antibody, generated in-house using rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for use in a variety of research applications, including Western blotting and immunofluorescence.HELZ2 is a multifunctional protein involved in diverse cellular processes, including transcriptional regulation, DNA repair, and cell cycle progression.

Dysregulation of HELZ2 has been implicated in various diseases, including cancer and developmental disorders, highlighting its importance in biological pathways. By targeting the HELZ2 protein, researchers can gain insights into its functions and potential therapeutic implications in disease settings.Overall, the HELZ2 Polyclonal Antibody is a reliable tool for studying the roles and mechanisms of the HELZ2 protein in cellular processes, offering new avenues for research in cancer biology, developmental biology, and beyond.

Antibody Name:HELZ2 Antibody (PACO05571)
Antibody SKU:PACO05571
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:Human
Immunogen:Synthesized peptide derived from the Internal region of human PRIC285.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:PRIC285; KIAA1769; Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein; ATP-dependent helicase PRIC285; PPAR-α-interacting complex protein 285; PPAR-γ DNA-binding domain-interacting protein 1; PDIP1; PP
UniProt Protein Function:PRIC285: Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. Belongs to the DNA2/NAM7 helicase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: C2H2-type zinc finger protein; EC 3.6.4.-; Transcription, coactivator/corepressor; Nuclear receptor co-regulator; EC 3.6.1.-; HelicaseChromosomal Location of Human Ortholog: 20q13.33Cellular Component: nucleoplasm; membraneMolecular Function: protein binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; metal ion binding; helicase activity; ATP bindingBiological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BYK8
NCBI GenInfo Identifier:156105693
NCBI Gene ID:85441
NCBI Accession:NP_001032412.2
UniProt Secondary Accession:Q9BYK8,Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094
UniProt Related Accession:Q9BYK8
Molecular Weight:294,651 Da
NCBI Full Name:helicase with zinc finger domain 2 isoform 1
NCBI Synonym Full Names:helicase with zinc finger 2, transcriptional coactivator
NCBI Official Symbol:HELZ2  
NCBI Official Synonym Symbols:PDIP-1; PRIC285  
NCBI Protein Information:helicase with zinc finger domain 2; PDIP1; PRIC complex; ATP-dependent helicase PRIC285; PPARG-DBD-interacting protein 1; PPAR gamma DBD-interacting protein 1; PPAR-gamma DBD-interacting protein 1; PPAR-alpha-interacting complex protein 285; PPARgamma-DNA
UniProt Protein Name:Helicase with zinc finger domain 2
UniProt Synonym Protein Names:ATP-dependent helicase PRIC285; Helicase with zinc finger 2, transcriptional coactivator; PPAR-alpha-interacting complex protein 285; PPAR-gamma DNA-binding domain-interacting protein 1; PDIP1; PPAR-gamma DBD-interacting protein 1; Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein
Protein Family:Helicase with zinc finger domain
UniProt Gene Name:HELZ2  
UniProt Entry Name:HELZ2_HUMAN

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