The HECW2 Antibody (PACO03044) is a highly specific and sensitive tool for research involving HECW2, a protein associated with the regulation of various biological processes. This polyclonal antibody, produced in rabbits, has been rigorously tested and validated for use in Western blot applications with human samples. By targeting the HECW2 protein, researchers can effectively study its function and role in cellular pathways, particularly in the fields of cell biology and cancer research.HECW2 is a key player in the regulation of protein stability and degradation, making it a promising target for investigating mechanisms of disease development and progression. Its involvement in cellular processes such as cell cycle regulation and DNA repair underscores its importance in maintaining normal cell function.
By gaining insights into the function of HECW2, researchers can potentially identify novel therapeutic targets for diseases characterized by dysregulated protein turnover.Overall, the HECW2 Antibody (PACO03044) provides researchers with a valuable tool for studying the biological functions of HECW2 and its potential implications in disease pathogenesis. Its high specificity and sensitivity make it an essential component in advancing our understanding of cellular mechanisms and identifying new therapeutic strategies for various diseases.
Antibody Name:
HECW2 Antibody
Antibody SKU:
PACO03044
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human NEDL2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
HECW2; KIAA1301; NEDL2; E3 ubiquitin-protein ligase HECW2; HECT; C2 and WW domain-containing protein 2; NEDD4-like E3 ubiquitin-protein ligase 2
UniProt Protein Function:
HECW2: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.-; Ligase; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 2q32.3Cellular Component: cytoplasm; nucleusMolecular Function: ubiquitin-protein ligase activityBiological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process
