The HE4 (WFDC2) Monoclonal Antibody is a valuable tool for researchers studying HE4, a protein that has been identified as a potential biomarker for ovarian cancer. This monoclonal antibody, produced in mice, exhibits high specificity and sensitivity for detecting HE4 in human samples. Validated for use in various applications, including immunohistochemistry and ELISA, this antibody binds specifically to the HE4 protein, allowing for precise detection and quantification in different research settings.
HE4, also known as human epididymis protein 4, is overexpressed in ovarian cancer cells and has been shown to be a promising marker for early detection and monitoring of this deadly disease. By targeting HE4 with monoclonal antibodies like this one, researchers can gain valuable insights into the roles of HE4 in cancer development and progression. This knowledge may lead to improved diagnostic tools and therapeutic strategies for ovarian cancer patients, ultimately improving outcomes in the clinic.
Product Name:
HE4/WFDC2 Monoclonal Antibody
SKU:
CAB21953
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 31-124 of human HE4/WFDC2 (NP_006094.3).
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.
Purification Method:
Affinity purification
Gene ID:
10406
Clone Number:
ARC53195
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of OVCAR3, using HE4/WFDC2 antibody (CAB21953) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
