The HDAC9 Rabbit Monoclonal Antibody (CAB2226) is a high-quality antibody designed for research involving HDAC9, a histone deacetylase protein known to be involved in epigenetic regulation and gene expression. This antibody, generated in rabbits, exhibits high specificity and sensitivity for HDAC9 in human samples, making it ideal for use in Western blot and immunohistochemistry applications.HDAC9 plays a crucial role in the regulation of gene expression through the deacetylation of histone proteins, leading to changes in chromatin structure and transcriptional repression. Dysregulation of HDAC9 has been linked to various diseases, including cancer, cardiovascular disorders, and neurodegenerative diseases.
Understanding the function and regulation of HDAC9 is essential for developing targeted therapies for these conditions.With its high reactivity and specificity, the HDAC9 Rabbit Monoclonal Antibody (CAB2226) is a valuable tool for researchers studying the role of HDAC9 in epigenetic regulation and disease development. Its ability to detect HDAC9 expression in various cell types allows for detailed analysis and characterization of this important protein, paving the way for advancements in the fields of genetics, oncology, and personalized medicine.
Product Name:
HDAC9 Rabbit Monoclonal Antibody
SKU:
CAB2226
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HDAC9 (Q9UKV0).
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
Purification Method:
Affinity purification
Gene ID:
9734
Clone Number:
ARC0735
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using HDAC9 Rabbit mAb (CAB2226) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
