The HDAC8 Rabbit Monoclonal Antibody (CAB8865) is a powerful tool for researchers studying histone deacetylase 8 (HDAC8), a key enzyme involved in epigenetic regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting HDAC8 in human samples, making it an invaluable asset for experiments such as Western blot analysis.HDAC8 plays a crucial role in gene expression by removing acetyl groups from histone proteins, influencing chromatin structure and ultimately impacting cellular processes such as cell cycle regulation and development.
Dysregulation of HDAC8 has been implicated in various diseases, including cancer and neurological disorders, highlighting its potential as a therapeutic target.By utilizing the HDAC8 Rabbit Monoclonal Antibody, researchers can gain valuable insights into the function and regulation of HDAC8 in different cell types and disease contexts. This antibody is an essential tool for advancing our understanding of epigenetic mechanisms and potentially identifying new avenues for targeted therapy development.
Product Name:
HDAC8 Rabbit Monoclonal Antibody
SKU:
CAB8865
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HDAC8 (Q9BY41).
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
55869
Clone Number:
ARC1331
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using HDAC8 Rabbit mAb (CAB8865) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
