The HDAC6 Polyclonal Antibody (CAB1732) is a valuable tool for researchers studying histone deacetylase 6 (HDAC6), an enzyme involved in cell regulation and protein homeostasis. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot and immunohistochemistry applications.HDAC6 is known to play important roles in various cellular processes, including cell migration, cytoskeleton organization, and response to cellular stress. Dysregulation of HDAC6 has been implicated in several diseases, making it a promising target for therapeutic interventions.
The CAB1732 antibody binds specifically to HDAC6, enabling precise detection and analysis in different cell types.Researchers in the fields of biology, oncology, and neurology will find this antibody particularly useful for studying the function and localization of HDAC6 in normal and diseased tissues. By understanding the mechanisms of HDAC6 activity, novel therapeutic strategies may be developed to target diseases such as cancer, neurodegenerative disorders, and autoimmune conditions.
Product Name:
HDAC6 Rabbit Polyclonal Antibody
SKU:
CAB1732
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human HDAC6 (NP_006035.2).
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Purification Method:
Affinity purification
Gene ID:
10013
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using HDAC6 Rabbit pAb (CAB1732) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
